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Tiredness Doesn't Go Away Even After Sleeping? Scientists Discovered The Real Reason For Body's 'battery' Not Being Recharged

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Amit Kumar
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December 19, 2025
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Fatigue that does not go away even with rest: Scientists discovered the mystery of 'Chronic Fatigue Syndrome' (Image Source: AI-Generated)

Prater, New Delhi. Researchers from Macquarie University in Australia conducted a study, the results of which have been published in the journal 'Cell Reports Medicine'. This research has made it clear that this fatigue is not just mental but is the result of deep biological turmoil going on within the body.

broken balance of blood and energy

The research team compared blood samples from 61 people with CFS with healthy people. The analysis found that the balance of the blood vessels (vascular) and immune system (immune system) of the patients suffering from this disease gets completely disturbed.

The most shocking thing was that the patients' cells were not getting enough energy and blood flow. Due to this disruption in the functioning of the body, a person feels extremely tired all the time, which also affects his sleep, mood and concentration.

'Energy Stress' and White Blood Cells

According to Benjamin Heng, the lead author of the research, clear signs of 'energy stress' have been found in the white blood cells of CFS patients. To understand this, scientists examined ATP, which is the main source of energy for cells.

This energy is essential for complex functions like muscle contraction and DNA formation, the lack of which leaves patients physically paralyzed.

simultaneous failure of multiple systems

This study is also special because it looked at the dysfunction of multiple systems simultaneously within the same patient. The research found that:

Don't mistake it for 'laziness'

Benjamin Heng says that chronic fatigue syndrome is a heterogeneous disease. In this, the way different biological systems react with each other decides how severe the symptoms of the disease will be. This research can prove to be a big step towards better diagnosis and treatment of this disease in future.

Remember, CFS is not simple laziness, but a serious biological condition where the body's 'battery' stops recharging at the cellular level.

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